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This response difference is consistent with previous reports in zebrafish identifying initial BPA-induced hyperactivity in response to acute/early exposure 34,35 but later reductions in locomotor behavior 35

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In vitro , Bushen Jiedu Tongluo Formula inhibits the proliferation, migration, and capillary-like tube formation of HMGB1 (100 ng/mL)-induced HUVECs at safe concentrations of 0.25, 0.5, and 1 mg/mL

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To further investigate this phenomenon, the expression of key genes and pathways involved in ferroptosis was analyzed in the livers of mice with iron overload, with or without theaflavins treatment